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High- dose nicotine patch therapy. Percentage of replacement and smoking cessation. A secondary objective was to assess short- and long- term smoking cessation rates. DESIGN: Randomized, double- blind, placebo- controlled inpatient/outpatient trial. SUBJECTS: Seventy- one cigarette smokers stratified according to light (n = 2. INTERVENTIONS: After baseline measures were obtained, subjects were randomly assigned to placebo or an 1. During the 6- day inpatient stay, daily nicotine and cotinine levels were determined from trough and peak blood samples. Outpatient patch therapy continued for 7 weeks following the hospital stay, and those initially assigned to placebo were randomly assigned to 1. At week 4, the dosage of those initially assigned to 4. MAIN OUTCOME MEASURES: Percentage of replacement of cotinine was calculated by dividing the steady- state levels attained during patch therapy by the corresponding baseline levels. Abstinence from smoking was verified by expired air carbon monoxide. Withdrawal symptoms and nicotine toxicity were assessed daily through questionnaires during the inpatient stay. Follow- up visits were at 3, 6, 9, and 1. RESULTS: There was a statistically significant relationship between baseline smoking rate and baseline trough and peak blood cotinine levels (rs = 0. P < . 0. 01 in both instances). A dose- response relationship was observed with higher patch doses, which produced a higher percentage of cotinine replacement and better withdrawal symptom relief. Only one subject (a light smoker assigned to the 4. There was a positive association between the week 2 patch dose and the biochemically confirmed abstinence at the end of patch therapy (P = . A higher percentage of cotinine replacement was associated with the higher 8- week smoking abstinence rate (P = . CONCLUSION: A 4. 4- mg/d dose of nicotine patch therapy appears to be safe for use in heavy smokers. Cigarette smoking rates can be used to estimate the initial nicotine patch dose. One patch is used per day. When applying the patch. There have been no reports of serious side effects from using the nicotine patch while smoking in studies. Nicotine patch is used for: Helping you to quit smoking. Nicotine patch is a smoking deterrent. It works by providing low levels of nicotine, which may help you to. Buy nicotine patches online at Boots. Boots stop smoking patches from Nicorette, NicQuitin, NicAssist and Nicotinell with step 1, 2 and 3 available. The nicotine patch is one of many nicotine replacement therapies proven to help ease nicotine withdrawal symptoms. Find out how to use it correctly. You use the strongest dose first and reduce it gradually over a period of 8 - 10 weeks. Nicotine patches branded a waste of time as study finds they don\'t help smokers quit long-term Former smokers just as likely to relapse if they used nicotine. High-dose nicotine patch therapy. Percentage of replacement and smoking. Cigarette smoking rates can be used to estimate the initial nicotine patch. What is the best nicotine patch, I need to help a love one stop. My strongest recommendation would be the gum for the nicotine intake and possibly. The patch is easy to use. The nicotine patch is long acting, controlling nicotine cravings and withdrawal symptoms for 24 hours at a time.Monitoring blood cotinine levels at baseline and steady state can be used for assessing the adequacy of nicotine replacement. Withdrawal symptom relief can be improved with more complete nicotine replacement. Achieving a greater percentage of nicotine replacement may increase the efficacy of nicotine patch therapy. What is the best nicotine patch, I need to help a love one stop smoking? I think this question violates the Community Guidelines. Chat or rant, adult content, spam, insulting other members,show more. I think this question violates the Terms of Service. Harm to minors, violence or threats, harassment or privacy invasion, impersonation or misrepresentation, fraud or phishing, show more. If you believe your intellectual property has been infringed and would like to file a complaint, please see our Copyright/IP Policy.
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